In the search for a solution to your hair growth problems, you have probably come across the terms dihydrotestosterone, DHT and DHT blockers. That's because male pattern baldness is inextricably linked to hormones like DHT. In this article, we will have a closer look at DHT blockers. The hair growth drugs that are increasingly mentioned as a possible solution against the most common cause of baldness: hereditary hair loss. We explore what DHT is, how hair loss is caused and what treatment options are available, both medical (finasteride) and natural (saw palmetto).
In the search for a solution to your hair growth problems, you have probably come across the terms dihydrotestosterone, DHT and DHT blockers. That's because male pattern baldness is inextricably linked to hormones like DHT. In this article, we will have a closer look at DHT blockers. The hair growth drugs that are increasingly mentioned as a possible solution against the most common cause of baldness: hereditary hair loss. We explore what DHT is, how hair loss is caused and what treatment options are available, both medical (finasteride) and natural (saw palmetto).
DHT is a hormone formed from testosterone. It is short for: dihydrotestosterone. This process is made possible by an enzyme called 5-alpha reductase. DHT is crucial for the development of male characteristics such as a deep voice, muscle growth, body hair and facial hair. And has an effect on hair growth. Ironically, it is also a major factor in male pattern baldness (androgenetic alopecia).
Why is DHT bad for your hair? In people who are genetically predisposed to it, the hair follicles on the scalp react hypersensitively to DHT. It binds to certain receptors of these hair follicles, leading to a shorter growth cycle. The hair growth phase (anagen phase) is shortened, causing hair to become thinner and grow shorter. In the long term, hair follicles shrivel up, eventually resulting in no more hair being produced. This results in hair loss, which in men usually starts at the temples and crown. Incidentally, women can also suffer from this form of hereditary hair loss. Then it's called female pattern hair loss.
It is important to know that not all hair follicles on the head are sensitive to DHT. The hairs on the sides and back of the head (the ‘eternal hair crown’) are less sensitive to it and are usually retained.
What are DHT blockers?
So how do DHT blockers work? DHT blockers can be substances that occur naturally, or can be developed to reduce the impact of DHT on hair follicles. Different terms are used interchangeably. So is DHT inhibitor, or DHT inhibitors.
They do this by preventing DHT from binding to receptors or by inhibiting the conversion of testosterone to DHT. By reducing the amount of it reaching the hair follicles, overstimulation is reduced, the hair growth cycle is prolonged, and hair loss is delayed. There are different types of DHT blockers, from prescription drugs available, to natural remedies.
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The most well-known and scientifically researched DHT blocking medications are drugs such as finasteride and dutasteride:
Finasteride: This drug inhibits the conversion of testosterone to DHT, reducing the amount of DHT production in the body. It blocks about 70% of the conversion of testosterone to DHT. Finasteride is an effective treatment for men in the early to middle stages of hair loss. It is important to note that you need a prescription to obtain finasteride.
Dutasteride: This drug works in the same way as finasteride, but is more potent. It blocks about 90% of the conversion of testosterone to DHT. Dutasteride has a longer half-life than finasteride, so it remains active in the body for longer. Also, dutasteride is available only on prescription.
While these drugs are effective as hair loss treatments for male pattern baldness, it is good to be aware of the possible side effects. Erectile dysfunction and decreased libido are possible side effects. There is also research into a possible link with an increased risk of prostate cancer. Always discuss these risks with your doctor before starting any treatment.
70%
DHT blocking effect of finasteride
90%
DHT blocking effect of dutasteride
Natural DHT blockers: what is possible?
For those who prefer not to take drugs for treating male pattern hair loss, there are also natural options that may be able to help block them. Although the scientific basis for these remedies is often less robust, these DHT blockers against hereditary baldness are used by many people as part of treatment:
Saw palmetto (saw palmetto extract): This extract can help lower DHT levels in the body and reduce hair loss. Although less effective than finasteride, several studies have proven its effectiveness.
Green tea: The antioxidants in green tea, such as polyphenols and EGCG, could potentially lower DHT levels.
It is important to remember that the effectiveness of natural agents for hair regrowth such as saw palmetto and green tea extract can vary, and more scientific research is needed to fully understand their effects.
Besides the well-known drugs, there are other hair loss treatments that are considered DHT inhibitors:
Low Level Laser Therapy (LLLT): This laser therapy can reduce hair loss by improving the energy balance of cells in the scalp. Whether it also has an effect on DHT is not fully known.
Minoxidil: This is usually a topical lotion that improves blood circulation in the scalp. This drug has no effect on the level of DHT in the body. It therefore doesn't tackle the root of the cause of male pattern baldness: DHT. Ketoconazole shampoo: This shampoo is mainly used against fungal infections, but can also help with hair loss by inhibiting the local action of DHT. Studies suggest that ketoconazole has mild anti-androgenic effects. It can block the action of DHT in the scalp, reducing the damage to hair follicles.
Biotin supplements. Biotin plays an important role in healthy and normal hair growth. Biotin belongs to the vitamin B family and can contribute to hair growth if your hair is thinning, and you want a full head of hair.
The best hair loss treatments against male pattern baldness
Tackling male pattern baldness is a personal journey. Blocking the hormone called DHT can be an important part of that journey to a full head of hair. Whether you opt for a drug or enter into a treatment that includes more natural remedies, it is essential to be well-informed and consult with a specialist. The latter can help you choose the right treatment method, taking into account your personal situation and medical background. This applies to both men and women.
A healthy lifestyle and a balanced diet, rich in vitamins and minerals, are important anyway to support the health of your hair.
